Gel Electrophoresis Reagents and Buffers
ABclonal Technology YME1L1 Rabbit pAb
The protein encoded by this gene is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies. Three transcript variants encoding different isoforms have been found for this gene.
![ABclonal Technology [KO Validated] ITCH Rabbit mAb](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000134926.jpg-250.jpg)
ABclonal Technology [KO Validated] ITCH Rabbit mAb
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
ABclonal Technology SCN3B Rabbit pAb
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified.
Abcam Phosphate Assay Kit - PiColorLockTM.
Phosphate Assay Kit - PiColorLockTM.
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology CABLES1 Rabbit pAb
This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID 17982127).Multiple transcript variants encoding different isoforms have been found for this gene.
ABclonal Technology ORP1 Rabbit mAb
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist, they encode different isoforms.
Biotium Primary Antibody Human IgG Fc N2508.HFC CF583R 1/EA
Anti-Human IgG (Fc) rVHH (N2508 HFC) is a recombinant Alpaca VHH antibody that recognizes the Fc domain of human IgG and is validated for IF and flow Red fluorescent STORM-compatible CF583R dye has Ex/Em at 583/606 nm Unit size 500 uL at 0 1 mg/mL
ABclonal Technology COPG2 Rabbit pAb
Predicted to enable structural molecule activity. Involved in intra-Golgi vesicle-mediated transport. Part of COPI vesicle coat.
ABclonal Technology Raptor Rabbit pAb
This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene.
ABclonal Technology RABL3 Rabbit pAb
Predicted to enable GTP binding activity, GTPase activity, and protein homodimerization activity. Involved in regulation of Ras protein signal transduction and regulation of protein lipidation. Predicted to be active in endomembrane system. Implicated in pancreatic cancer.
ABclonal Technology COQ10B Rabbit pAb
Predicted to enable ubiquinone binding activity. Predicted to be involved in cellular respiration and ubiquinone biosynthetic process. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion.
ABclonal Technology SRSF3 Rabbit mAb
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other non-coding, have been found for this gene.
ABclonal Technology USP13 Rabbit pAb
Enables several functions, including BAT3 complex binding activity, chaperone binding activity, and cysteine-type peptidase activity. Involved in several processes, including maintenance of unfolded protein involved in ERAD pathway, regulation of cellular catabolic process, and regulation of transcription, DNA-templated. Acts upstream of or within protein deubiquitination and protein stabilization. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus.
ABclonal Technology NDUFB3 Rabbit pAb
This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which is the first enzyme in the electron transport chain of mitochondria. This protein localizes to the inner membrane of the mitochondrion as a single-pass membrane protein. Mutations in this gene contribute to mitochondrial complex 1 deficiency. Alternative splicing results in multiple transcript variants encoding the same protein. Humans have multiple pseudogenes of this gene.
ABclonal Technology NLRP12 Rabbit pAb
This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants.